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KMID : 0624620200530090458
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BMB Reports
2020 Volume.53 No. 9 p.458 ~ p.465
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Implications of telomerase reverse transcriptase in tumor metastasis
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Zou Yongkang
Cong Yu-Sheng
Zhou Junzhi
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Abstract
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Metastasis is the main culprit of the great majority of cancerrelated deaths. However, the complicated process of the invasion-metastasis cascade remains the least understood aspect of cancer biology. Telomerase plays a pivotal role in bypassing cellular senescence and sustaining the cancer progression by maintaining telomere homeostasis and genomic integrity. Telomerase reverse transcriptase (TERT) exerts a series of fundamental functions that are independent of its enzymatic cellular activity, including proliferation, inflammation, epithelia-mesenchymal transition (EMT), angiogenesis, DNA repair, and gene expression. Accumulating evidence indicates that TERT may facilitate most steps of the invasion-metastasis cascade. In this review, we summarize important advances that have revealed some of the mechanisms by which TERT facilitates tumor metastasis, providing an update on the non-canonical functions of telomerase beyond telomere maintaining.
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KEYWORD
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Cellular senescence, EMT, Metastasis, Telomerase, TERT
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